Metabolic activation of four drugs in the eye mosaic assay measuring principally mitotic recombination in Drosophila melanogaster: differences in strain susceptibility and route of exposure.

Abstract excerpt

One mycotoxin and three therapeutic drugs widely used in developing countries were examined for genotoxic activity by means of the w/w + somatic recombination assay. Streptozotocin (SZ), an antibiotic antineoplastic agent, gave a frequency of light spots almost one order of magnitude higher than those obtained with the carcinogen mycotoxin sterigmatocystin (STC), the antiprotozoal and antimicrobial metronidazole...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dose-Response Relationship, Drug
• Share to Drosophila melanogaster