Article
Metabolic activation of four drugs in the eye mosaic assay measuring principally mitotic recombination in Drosophila melanogaster: differences in strain susceptibility and route of exposure.
Mutation research - 1 Mar 1994
Rodriguez-Arnaiz R, Aranda J H
Abstract excerpt
One mycotoxin and three therapeutic drugs widely used in developing countries were examined for genotoxic activity by means of the w/w + somatic recombination assay. Streptozotocin (SZ), an antibiotic antineoplastic agent, gave a frequency of light spots almost one order of magnitude higher than...
Topics
- Animals
- Biotransformation
- Dose-Response Relationship, Drug
- Drosophila melanogaster
- Drug Resistance
- Eye
- Female
- Genotype
- Griseofulvin
- Insecticides
- Larva
- Metronidazole
- Molecular Structure
- Mosaicism
- Mutagenicity Tests
- Mutagens
- Oviposition
- Species Specificity