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Article

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?

PLoS pathogens - 1 Feb 2006

Boyer Paul L, Sarafianos Stefan G, Clark Patrick K, Arnold Eddy, Hughes Stephen H

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) develops resistance to all available drugs, including the nucleoside analog reverse transcriptase inhibitors (NRTIs) such as AZT. ATP-mediated excision underlies the most common form of HIV-1 resistance to AZT. However, clinical data suggest that when HIV-2 is challenged with AZT, it usually accumulates resistance mutations that cause AZT resistance by reduced...

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Identifiers

PMID: 16485036
DOI: 10.1371/journal.ppat.0020010
PMCID: PMC1364504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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