Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

doi:10.1073/pnas.91.3.1133

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Article

Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1994

Wysolmerski J J, Broadus A E, Zhou J, Fuchs E, Milstone L M, Philbrick W M

Abstract excerpt

Parathyroid hormone-related peptide (PTHrP) was initially discovered as the cause of the syndrome of humoral hypercalcemia of malignancy. Subsequently, the PTHrP gene has been shown to be expressed in a wide variety of normal tissues, including skin. Because the biological function of PTHrP in sk...

Topics

Animals
Female
Gene Expression
Hair
Humans
Keratins
Mice
Mice, Transgenic
Parathyroid Hormone
Parathyroid Hormone-Related Protein
Phenotype
Promoter Regions, Genetic
Proteins
Skin

Source

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Identifiers

PMID: 7508121
DOI: 10.1073/pnas.91.3.1133
PMCID: PMC521468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7508121-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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