Article
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1994
Wysolmerski J J, Broadus A E, Zhou J, Fuchs E, Milstone L M, Philbrick W M
Abstract excerpt
Parathyroid hormone-related peptide (PTHrP) was initially discovered as the cause of the syndrome of humoral hypercalcemia of malignancy. Subsequently, the PTHrP gene has been shown to be expressed in a wide variety of normal tissues, including skin. Because the biological function of PTHrP in skin remains unknown, we used the human keratin 14 promoter to target overexpression of PTHrP to the skin of transgenic...
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