Article
Parathyroid hormone hormone-related protein and the PTH receptor regulate angiogenesis of the skin.
The Journal of investigative dermatology - 1 Sept 2006
Diamond A Godwin, Gonterman Ryan M, Anderson Aileen L, Menon Keshav, Offutt Carlos D, Weaver Chad H, Philbrick William M, Foley John
Abstract excerpt
In developing organs, parathyroid hormone (PTH)/parathyroid hormone-related protein (PTHrP) receptor (PPR) signaling inhibits proliferation and differentiation of mesenchyme-derived cell types resulting in control of morphogenic events. Previous studies using PPR agonists and antagonists as well as transgenic overexpression of the PPR ligand PTHrP have suggested that this ligand receptor combination might...
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