Article
A dimensional impulsive-aggressive phenotype is associated with the A218C polymorphism of the tryptophan hydroxylase gene: a pilot study in well-characterized impulsive inpatients.
American journal of medical genetics - 8 Jul 2002
Staner Luc, Uyanik Gökhan, Correa Humberto, Tremeau Fabien, Monreal José, Crocq Marc-Antoine, Stefos Grigori, Morris-Rosendahl Deborah J, Macher Jean Paul
Abstract excerpt
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin, and association and linkage studies of its variants in suicidal and impulsive-aggressive behavior have brought conflicting results. This pilot study was designed to investigate whether TPH A218C genotypes could be associated with impulsive behavioral tendencies (IBTs) in consecutively admitted nonpsychotic nonorganic...
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