Epitope mapping studies with neutralizing and non-neutralizing monoclonal antibodies to the G1 and G2 envelope glycoproteins of Hantaan virus.

doi:10.1006/viro.1993.1652

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Article

Epitope mapping studies with neutralizing and non-neutralizing monoclonal antibodies to the G1 and G2 envelope glycoproteins of Hantaan virus.

Virology - 1 Dec 1993

Wang M, Pennock D G, Spik K W, Schmaljohn C S

Abstract excerpt

Epitopes recognized by three G1-specific and two G2-specific neutralizing monoclonal antibodies to Hantaan virus were mapped by sequence analyses of the complete M genome segments of neutralization escape variant viruses. For each variant, we detected nucleotide sequence substitutions which resulted in a single amino acid change in either the G1 or G2 protein. Serological properties of the variant viruses...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Antibodies, Viral
Baculoviridae
Epitopes
Genes, Viral
Genetic Variation
Hantaan virus
Hemagglutination Inhibition Tests
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Precipitin Tests

Recombinant Proteins

Sequence Analysis, DNA

Sequence Deletion

Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 7504368
DOI: 10.1006/viro.1993.1652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7504368-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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