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Generation of an HFRS patient‐derived neutralizing recombinant antibody to Hantaan virus G1 protein and definition of the neutralizing domain

15 Nov 2002

Abstract excerpt

Hantaan virus (HTNV) in the Hantavirus genus, family Bunyaviridae, is the major cause of severe hemorrhagic fever with renal syndrome (HFRS). We prepared a combinatorial phage display library of human Fabs to HTNV from RNA extracted from the blood lymphocytes of a convalescent HFRS patient. We selected two G1 glycoprotein-specific clones and one nucleocapsid protein (N)-specific clone from the Fab library for...

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PMID: 12436484
DOI: 10.1002/jmv.10259

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