Article
Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies.
Molecular immunology - 1 Apr 2013
Rockman Steve, Camuglia Sarina, Vandenberg Kirsten, Ong Chi, Baker Mark A, Nation Roger L, Li Jian, Velkov Tony
Abstract excerpt
The induction of neutralising antibodies to the viral surface glycoprotein, haemagglutinin (HA) is considered the cornerstone of current seasonal and pandemic influenza vaccines. Mapping of neutralising epitopes using monoclonal antibodies (mAbs) helps define mechanisms of antigenic drift, neutralising escape and facilitates pre-pandemic vaccine design. In the present study we reverse engineered the antigenic...
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