Article
Ultrastructural allelic variation in HLA-DQB1 promoter elements.
Human immunology - 1 Aug 1995
Leech N, Sorrentino R, McCulloch D K, Nepom G T
Abstract excerpt
Sequence variation among HLA class II promoter elements may contribute to functional differences in transcriptional regulation of different class II alleles. In addition to influencing the binding sites for nuclear transcription factors, promoter polymorphism may also alter intrinsic structural properties of the DNA strands, such as conformation and curvature, which influence the formation of stable transcription...
Topics
- Alleles
- Animals
- Base Sequence
- Diabetes Mellitus, Type 1
- Genetic Variation
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Humans
- Molecular Sequence Data
- Pan troglodytes
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational