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Article

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.

The Journal of biological chemistry - 14 Nov 2003

Rowlinson Scott W, Kiefer James R, Prusakiewicz Jeffery J, Pawlitz Jennifer L, Kozak Kevin R, Kalgutkar Amit S, Stallings William C, Kurumbail Ravi G, Marnett Lawrence J

Abstract excerpt

A variety of drugs inhibit the conversion of arachidonic acid to prostaglandin G2 by the cyclooxygenase (COX) activity of prostaglandin endoperoxide synthases. Several modes of inhibitor binding in the COX active site have been described including ion pairing of carboxylic acid containing inhibitors with Arg-120 of COX-1 and COX-2 and insertion of arylsulfonamides and sulfones into the COX-2 side pocket. Recent...

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Identifiers

PMID: 12925531
DOI: 10.1074/jbc.M305481200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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