Article
Prostaglandin endoperoxide synthase. The aspirin acetylation region.
The Journal of biological chemistry - 15 Jun 1992
Shimokawa T, Smith W L
Abstract excerpt
Aspirin selectively acetylates Ser-530 of prostaglandin endoperoxide (PGH) synthase-1. This causes inactivation of the cyclooxygenase activity of the enzyme, but does not appreciably affect its peroxidase activity. Although the aspirin-acetylated enzyme is inactive, we found that PGH synthase-1 i...
Topics
- Acetylation
- Amino Acid Sequence
- Aspirin
- Base Sequence
- Blotting, Western
- Cell Line
- Cyclooxygenase Inhibitors
- Electrophoresis, Polyacrylamide Gel
- Molecular Sequence Data
- Mutation
- Trypsin