Article
The unusual reversion properties of a mitochondrial mutation in the structural gene of subunit I of cytochrome oxidase of Saccharomyces cerevisiae reveal a probable histidine ligand of the redox center.
Current genetics - 1 Feb 1992
Netter P, Robineau S, Sirand-Pugnet P, Fauvarque M O
Abstract excerpt
We have analyzed a mutation in the mitochondrial gene oxi3 coding for subunit I of cytochrome-oxidase in the yeast Saccharomyces cerevisiae. This mutation replaces one of the seven invariant histidines of the polypeptide (position 378) by a tyrosine, and leads to a respiratory deficient phenotype...
Topics
- Amino Acid Sequence
- Electron Transport Complex IV
- Genes, Fungal
- Histidine
- Ligands
- Mitochondria
- Molecular Sequence Data
- Mutation
- Oxidation-Reduction
- Oxygen Consumption
- Protein Conformation
- Saccharomyces cerevisiae
- Sequence Alignment