Article
Molecular evidence for the direct involvement of a protein kinase C in developmental and behavioural susceptibility to tumour-promoting phorbol esters in Caenorhabditis elegans.
The Biochemical journal - 15 Nov 1995
Tabuse Y, Sano T, Nishiwaki K, Miwa J
Abstract excerpt
The nematode Caenorhabditis elegans displays developmental and behavioural sensitivity to tumour-promoting phorbol esters. This sensitivity involves the gene tpa-1, which encodes two protein kinase C isoforms, TPA-1A and TPA-1B. Here we report the molecular nature of the sensitivity in this anima...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Carcinogens
- DNA Transposable Elements
- Genes, Helminth
- Immunoblotting
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Kinase C
- Protein-Tyrosine Kinases
- Recombinant Fusion Proteins
- Sequence Analysis