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Article

The type 1 diabetes locus Idd6 controls TLR1 expression.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2007

Vallois David, Grimm Christina H, Avner Philip, Boitard Christian, Rogner Ute Christine

Abstract excerpt

The Idd6 locus on mouse chromosome 6, which controls the development of type 1 diabetes in the NOD mouse, affects proliferation rates of T cells and the activity of regulatory CD4+CD25+ T cells. Using a transcriptional profiling approach, we show that splenocytes and thymocytes from diabetes-resistant Idd6 NOD.C3H-congenic mouse strains exhibit a constitutive and specific down-regulation of Toll-like receptor 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17785827
DOI: 10.4049/jimmunol.179.6.3896

Genes

TLR1
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The type 1 diabetes locus Idd6 controls TLR1 expression.PMID 17785827Read ↗

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