Article
Vitamin D receptor genotypes in primary hyperparathyroidism.
Nature medicine - 1 Dec 1995
Carling T, Kindmark A, Hellman P, Lundgren E, Ljunghall S, Rastad J, Akerström G, Melhus H
Abstract excerpt
Vitamin D and parathyroid hormone (PTH) constitute the main regulators of systemic calcium homeostasis. As well as its calcaemic effects, active vitamin D3(1,25(OH)2D3) has a direct regulatory role on parathyroid cells. Active vitamin D3 acts via its receptor (VDR), and binding of the ligand-receptor complex to specific promoter regions of the PTH gene inhibits transcription. Active vitamin D3 constitutes a...
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