Article
Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism - 1 Jun 1997
Carling T, Ridefelt P, Hellman P, Rastad J, Akerström G
Abstract excerpt
Calcitriol acts via its receptor (VDR) and inhibits PTH secretion and parathyroid cell proliferation. Increased prevalence of the polymorphic VDR alleles b, a, and T has been demonstrated in sporadic primary hyperparathyroidism. Sixty-two patients with primary hyperparathyroidism due to parathyroid adenoma (mean age, 69.5 +/- 1.4 yr) were genotyped for these VDR polymorphisms. Dispersed cells of the adenomas were...
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