Article
Vitamin D receptor (VDR) and parathyroid hormone messenger ribonucleic acid levels correspond to polymorphic VDR alleles in human parathyroid tumors.
The Journal of clinical endocrinology and metabolism - 1 Jul 1998
Carling T, Rastad J, Akerström G, Westin G
Abstract excerpt
Calcitriol, via its receptor (VDR) is a main regulator of PTH secretion and parathyroid cell proliferation. Recently, marked overrepresentation of the polymorphic VDR alleles b, a, and T was found in patients with primary hyperparathyroidism (pHPT), which suggests pathogenic importance in the dis...
Topics
- Adenoma
- Aged
- Alleles
- Calcitriol
- Female
- Haplotypes
- Heterozygote
- Homozygote
- Humans
- Male
- Parathyroid Hormone
- Parathyroid Neoplasms
- Polymorphism, Genetic
- RNA, Messenger
- Receptors, Calcitriol