Article
Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer.
Cancer research - 15 Apr 2000
Berns E M, Foekens J A, Vossen R, Look M P, Devilee P, Henzen-Logmans S C, van Staveren I L, van Putten W L, Inganäs M, Meijer-van Gelder M E, Cornelisse C, Claassen C J, Portengen H, Bakker B, Klijn J G
Abstract excerpt
TP53 has been implicated in regulation of the cell cycle, DNA repair, and apoptosis. We studied, in primary breast tumors through direct cDNA sequencing of exons 2-11, whether TP53 gene mutations can predict response in patients with advanced disease to either first-line tamoxifen therapy (202 patients, of whom 55% responded) or up-front (poly)chemotherapy (41 patients, of whom 46% responded). TP53 mutations were...
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