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Article

Biochemical prototype for familial thrombosis. A study combining a functional protein C mutation and factor V Leiden.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1995

Kalafatis M, Lu D, Bertina R M, Long G L, Mann K G

Abstract excerpt

Resistance to activated protein C (APC) is associated with a single amino acid substitution in factor V (Arg506-->Gln, factor V Leiden) that results in delayed inactivation of the molecule by APC. The mutation is present in 20% of patients with a first episode of deep venous thrombosis. Arterial and venous thromboses are also associated with the type II protein C deficiency (protein CVermont). In protein...

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Source

Identifiers

PMID: 7489240
DOI: 10.1161/01.atv.15.12.2181

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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