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Article

Impaired factor V-related anticoagulant mechanisms and deep vein thrombosis associated with A2086D and W1920R mutations.

Blood advances - 27 Jun 2023

Shimonishi Naruto, Ogiwara Kenichi, Yoshida Junko, Horie Kyoji, Nakajima Yuto, Furukawa Shoko, Takeyama Masahiro, Nogami Keiji

Abstract excerpt

Factor V (FV) plays pivotal roles in both procoagulant and anticoagulant mechanisms. Genetic mutations, FV-W1920R (FVNara) and FV-A2086D (FVBesançon), in the C1 and C2 domains of FV light chain, respectively, seem to be associated with deep vein thrombosis. However, the detailed mechanism(s) through which these mutations are linked to thrombophilia remains to be fully explored. The aim of this study was to...

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Source

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Identifiers

PMID: 36780344
DOI: 10.1182/bloodadvances.2022008918
PMCID: PMC10279549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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