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Article

MSH3 deficiency is not sufficient for a mutator phenotype in Chinese hamster ovary cells.

Carcinogenesis - 1 Feb 1999

Hinz J M, Meuth M

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the mutS homolog protein products MSH3 and MSH6, each in cooperation with MSH2, play well-defined and specific roles in the repair of DNA mismatches and nucleotide loops. The discrete functions of the human homologs hMSH3 and hMSH6 are less clear and current evidence suggests that the substrate specificity of these proteins may be less strict. To determine the role of MSH3...

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Source

Identifiers

PMID: 10069456
DOI: 10.1093/carcin/20.2.215

Genes

MSH3
MSH6
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MSH3 deficiency is not sufficient for a mutator phenotype in Chinese hamster ovary cells.PMID 10069456Read ↗

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.Semantic proximity Read ↗

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.Semantic proximity Read ↗

Mismatch repair deficiency associated with overexpression of the <i>MSH3</i> geneSemantic proximity Read ↗

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.Semantic proximity Read ↗

A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional overlap in mismatch repair by human MSH3 and MSH6.Semantic proximity Read ↗

Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivoSemantic proximity Read ↗

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Semantic proximity Read ↗

Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.Semantic proximity Read ↗

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.Semantic proximity Read ↗

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability.Semantic proximity Read ↗

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