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Article

Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.

Molecular cancer therapeutics - 1 Aug 2005

Nonaka Takahiro, Nishibashi Kunika, Itoh Yoshifumi, Yana Ikuo, Seiki Motoharu

Abstract excerpt

Membrane type 1 matrix metalloproteinase (MT1-MMP) is a potent modulator of the pericellular environment and promotes tumor cell invasion and proliferation in many types of tumor. The activation of proMMP-2 and processing of collagen I by MT1-MMP have been thought to be important for its tumor-promoting function. These activities can be inhibited by mutant forms of MT1-MMP lacking the catalytic domain. However,...

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PMID: 16093431
DOI: 10.1158/1535-7163.MCT-05-0127

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