Article
Huntington's disease and mitochondrial DNA deletions: event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?!
Cellular and molecular neurobiology - 1 Nov 2007
Banoei Mohammad Mehdi, Houshmand Massoud, Panahi Mehdi Shafa Shariat, Shariati Parvin, Rostami Maryam, Manshadi Masoumeh Dehghan, Majidizadeh Tayebeh
Abstract excerpt
The mitochondrial DNA (mtDNA) may play an essential role in the pathogenesis of the respiratory chain complex activities in neurodegenerative disorders such as Huntington's disease (HD). Research studies were conducted to determine the possible levels of mitochondrial defect (deletion) in HD patients and consideration of interaction between the expanded Huntingtin gene as a nuclear gene and mitochondria as a...
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