Article
Induction of increased permeability of polarized enterocyte monolayers by enterotoxigenic Escherichia coli heat-labile enterotoxin.
The American journal of tropical medicine and hygiene - 1 Mar 2011
Kreisberg Roderick B, Harper Jill, Strauman Maura C, Marohn Mark, Clements John D, Nataro James P
Abstract excerpt
Enterotoxigenic Escherichia coli (ETEC) is a common cause of acute diarrhea in resource-poor settings. We report that some ETEC strains elicit a reduction in trans-epithelial electrical resistance (TER) in polarized T84 epithelial cell monolayers. The effect was irreversible up to 48 hours after a three-hour infection and was observed with heat-labile enterotoxin (LT)-producing strains, but not with heat-stable...
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