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Article

Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity.

The journal of gene medicine - 1 Nov 2006

Halterman M W, Giuliano R E, Bowers W J, Federoff H J

Abstract excerpt

Given their generous transgene capacity and inherent neurotropism, herpes simplex virus (HSV-1)-based viral vectors are promising tools for gene delivery to the central nervous system. Despite their widespread pre-clinical use, vector toxicity remains a concern with regard to the use of herpes vectors in humans. One potential source of toxicity stems from the tegument-associated virion host shutoff protein (vhs),...

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Identifiers

PMID: 16989006
DOI: 10.1002/jgm.972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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