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Article

Variations in the phenotypic expression of an H-2-linked gene contributing to the control of IgE and haemagglutinating antibody responses to ovalbumin.

Annales d'immunologie - 1 Jan 2000

Mouton D, Prouvost-Danon A, Bouthillier Y, Mevel J C, Abadie A

Abstract excerpt

The genetic control of IgE- and HA-antibody responses to ovalbumin (OV) was investigated in H and L antibody responder lines of mice and in their hybrids. After immunization with threshold doses of OV (0.5 and 0.05 microgram OV) H mice were responder in terms of both HA and IgE antibody whereas L mice were non-responder. This trait was under monogenic control and the relevant gene was H-2-linked. The dominance...

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PMID: 7469386

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