Article
Genetic selection for resistance or susceptibility to oral tolerance imparts correlation to both Immunoglobulin E level and mast cell number phenotypes with a profound impact on the atopic potential of the individual.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2006
da Silva M F S, Nóbrega A, Ribeiro R C, Levy M S, Ribeiro O G, Tambourgi D V, Sant'Anna D A, da Silva A C
Abstract excerpt
BACKGROUND: Immunological oral tolerance is being studied with great interest due to its therapeutic potential in allergy and autoimmunity processes, although the cellular and molecular mechanisms linking these different phenomena remain elusive. In the present study, two mouse lines with extreme phenotypes for susceptibility [TS Line] or resistance [TR Line] to oral tolerance and their [TS x TR]F2 segregants...
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