Article
Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Tsao S C, Sugiyama Y, Shinmura K, Sawada Y, Nagase S, Iga T, Hanano M
Abstract excerpt
Recent kinetic studies using in situ perfused rat liver suggested that the hepatic uptake of extensively albumin-bound ligands is mediated primarily by direct interaction of the albumin-ligand complex with the hepatocyte surface rather than by the small unbound fraction of ligand, as has been generally believed [Ockner et al., Am. J. Physiol. 245, G13 (1983)]. In order to investigate this mechanism in vivo, rose...
Topics
- Animals
- Biological Transport, Active
- Cells, Cultured
- Dialysis
- Injections, Intravenous
- Liver
- Male
- Mutation
- Proteins
- Rats
- Rats, Inbred Strains