Article
Active avoidance behavior in the F1 progeny of male rats exposed to cyclophosphamide prior to fertilization.
Neurobehavioral toxicology and teratology - 1 Jan 2000
Adams P M, Fabricant J D, Legator M S
Abstract excerpt
The acquisition and extinction of a one-way active avoidance task was studied in 30 day old F1 progeny of male rats previously exposed to either acute or chronic treatment with cyclophosphamide (CP) prior to breeding with normal females. Chronic treatment (10 mg/kg/day x 5 days x 5 weeks) was given to adult F344 males followed by subsequent breeding with normal females (CP-S). Separate groups of males were given...
Topics
- Animals
- Animals, Newborn
- Avoidance Learning
- Cyclophosphamide
- Dose-Response Relationship, Drug
- Female
- Male
- Mutation
- Pregnancy
- Rats
- Rats, Inbred F344