Article
Revealing Behavioral Learning Deficit Phenotypes Subsequent to In Utero Exposure to Benzo(a)pyrene.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2016
McCallister Monique M, Li Zhu, Zhang Tongwen, Ramesh Aramandla, Clark Ryan S, Maguire Mark, Hutsell Blake, Newland M Christopher, Hood Darryl B
Abstract excerpt
To characterize behavioral deficits in pre-adolescent offspring exposed in utero to Benzo(a)pyrene [B(a)P], timed-pregnant Long Evans Hooded rats were treated with B(a)P (150, 300, 600, and 1200 µg/kg BW) or peanut oil (vehicle) on E14, 15, 16, and 17. Following birth, during the pre-weaning period, B(a)P metabolites were examined in plasma and whole brain or cerebral cortex from exposed and control offspring....
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