Article
Cyclophosphamide in the male rat: new pattern of anomalies in the third generation.
Journal of andrology - 1 Jan 2000
Dulioust E J, Nawar N Y, Yacoub S G, Ebel A B, Kempf E H, Auroux M R
Abstract excerpt
Several abnormalities, such as postnatal deaths and behavioral impairments, have been previously reported in the progeny of male rats exposed to the cytostatic drug cyclophosphamide 60 days prior to mating. The anomalies were transmitted to the second generation (F2). The present results concern the third generation. Two experimental groups have been studied: a hybrid group, resulting from crosses between control...
Topics
- Abnormalities, Drug-Induced
- Animals
- Behavior, Animal
- Cyclophosphamide
- Fertility
- Hybridization, Genetic
- Male
- Phenotype
- Rats
- Rats, Inbred Strains
- Reproduction