Article
Cyclophosphamide in the male rat: cerebral biochemical changes in progeny.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 1990
Auroux M R, Dulioust E M, Nawar N Y, Yacoub S G, Kempf E H, Ebel A B
Abstract excerpt
Adult male Wistar rats were treated with cyclophosphamide either alone or with both cyclophosphamide and vinblastine. They were then mated with virgin non-treated females. Examination of their offspring showed an increased post-natal mortality rate; and diminished learning capacity and spontaneou...
Topics
- Animals
- Brain
- Cerebral Cortex
- Choline O-Acetyltransferase
- Cyclophosphamide
- Frontal Lobe
- Hippocampus
- Male
- Mutation
- Norepinephrine
- Parietal Lobe
- Rats
- Rats, Inbred Strains