Article
Cyclophosphamide in the male rat: cerebral biochemical changes in progeny.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 1990
Auroux M R, Dulioust E M, Nawar N Y, Yacoub S G, Kempf E H, Ebel A B
Abstract excerpt
Adult male Wistar rats were treated with cyclophosphamide either alone or with both cyclophosphamide and vinblastine. They were then mated with virgin non-treated females. Examination of their offspring showed an increased post-natal mortality rate; and diminished learning capacity and spontaneous activity in the adults. These disorders were also found in the second generation, resulting from mating between...
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