Article
[Study of formation of amantidine and rimantidine resistant variants of influenza A2 subtype virus].
Voprosy virusologii - 1 Jan 2000
Il'enko V I
Abstract excerpt
Passages of influenza A2/Hong Kong/68 in developing chick embryos in the presence of amantadine and rimantadine were carried out and demonstrated rapid development of a resistant virus line under these conditions. Changes in the sensitivity of the virus to the drug were due to selection of resistant particles from genetically inhomogenous original virus strain. The rate of formation of the resistant population...
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