Article
[Study of formation of amantidine and rimantidine resistant variants of influenza A2 subtype virus].
Voprosy virusologii - 1 Jan 2000
Il'enko V I
Abstract excerpt
Passages of influenza A2/Hong Kong/68 in developing chick embryos in the presence of amantadine and rimantadine were carried out and demonstrated rapid development of a resistant virus line under these conditions. Changes in the sensitivity of the virus to the drug were due to selection of resist...
Topics
- Animals
- Antigens, Viral
- Chick Embryo
- Culture Techniques
- Drug Resistance, Microbial
- Genetic Variation
- Microbial Sensitivity Tests
- Orthomyxoviridae
- Virus Replication