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Article

The SOS chromotest: direct assay of the expression of gene sfiA as a measure of genotoxicity of chemicals.

Biochimie - 1 Jan 2000

Quillardet P, Huisman O, D'Ari R, Hofnung M

Abstract excerpt

We used a gene fusion, placing the lacZ gene encoding beta-galactosidase under the control of the sfiA promoter, to construct a new tester strain for genotoxic agents. The assay is performed in a few hours and involves simple enzymatic assays. The dose response curves contain a linear portion which enables to define the SOS Inducing Potency (SOSIP) of compounds. For the compounds tested SOSIPs extend over 7...

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PMID: 6814529
DOI: 10.1016/s0300-9084(82)80131-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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