Article
Protease inhibitors suppress the survival increase mediated by uncouplers in X-irradiated mammalian cells.
Biochimie - 1 Jan 2000
Michel S, Laval F
Abstract excerpt
When mammalian cells are incubated with an uncoupler of oxidative phosphorylation prior to and during X-irradiation, the survival and the mutation frequency are markedly increased. This process requires protein synthesis and is inhibited when the cells are plated in the presence of a protease inhibitor (antipain or leupeptin). These results suggest the existence of an error-prone DNA repair process in...
Topics
- Animals
- Carbonyl Cyanide m-Chlorophenyl Hydrazone
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- Cycloheximide
- DNA Repair
- Female
- Mutation
- Ovary
- Protease Inhibitors