Article
Fragilitas ossium: a new autosomal recessive mutation in the mouse.
The Journal of heredity - 1 Jan 2000
Guenet J L, Stanescu R, Maroteaux P, Stanescu V
Abstract excerpt
Fragilitas ossium, fro, is an often lethal recessive mutation that was discovered in a randombred stock of mice after treatment with the chemical mutagen tris(1-aziridinyl) phosphine-sulphine. The fro/fro mice have osteoporosis-bending and fracture of the long bones-that is associated with appare...
Topics
- Animals
- Disease Models, Animal
- Female
- Genes, Recessive
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Osteogenesis Imperfecta
- Osteoporosis
- Rodent Diseases
- Thiotepa