Article
Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
Mutation research - 1 Jan 2000
O'Donovan M R
Abstract excerpt
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and t...
Topics
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- Intercalating Agents
- Lung
- Mutagenicity Tests
- Mutagens
- Mutation
- Ouabain
- Structure-Activity Relationship