Article
International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents.
Mutation research - 1 Aug 1994
Anderson R D, Berger N A
Abstract excerpt
Drugs that interact with DNA topoisomerases I and II hold great promise for the treatment of cancer, however, like many other anti-cancer agents, they are a double-edged sword and may themselves cause mutation and cancer. In vitro studies show that clinically effective agents, such as etoposide, doxorubicin and others, stabilize a ternary complex where topoisomerase II is covalently linked to DNA. This complex...
Topics
- Animals
- Antineoplastic Agents
- Carcinogens
- Chromosome Aberrations
- DNA
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- Humans
- Mutagenicity Tests
- Mutagens
- Mutation