Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test.

Abstract excerpt

Earlier, we reported that vitamin A (retinol), in vitro, exhibits a strong inhibitory effect on the mutagenicity of aflatoxin B1 in the Ames Salmonella/microsome test. This paper reports the same inhibitory effect on the mutagenicity of an aminoazo dye, ortho-aminoazotoluene. Furthermore, the inhibitory effect was exerted by retinol esters such as retinol acetate and retinol palmitate, the latter being the...

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