Article
Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test.
Mutation research - 1 Jan 2000
Busk L, Ahlborg U G
Abstract excerpt
Earlier, we reported that vitamin A (retinol), in vitro, exhibits a strong inhibitory effect on the mutagenicity of aflatoxin B1 in the Ames Salmonella/microsome test. This paper reports the same inhibitory effect on the mutagenicity of an aminoazo dye, ortho-aminoazotoluene. Furthermore, the inh...
Topics
- Animals
- Azo Compounds
- Biotransformation
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Rats
- Rats, Inbred Strains
- Salmonella typhimurium
- Structure-Activity Relationship
- Vitamin A