Article
CL 64,855, a potent anti-Trypanosoma cruzi drug, is also mutagenic in the Salmonella/microsome assay.
Memorias do Instituto Oswaldo Cruz - 1 Jan 2000
Ferreira R C, Ferreira L C
Abstract excerpt
The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 and TA 102. Results indicate that CL 64,855 i...
Topics
- Mutagenicity Tests
- Mutation
- Salmonella typhimurium
- Thiadiazoles
- Trypanocidal Agents
- Trypanosoma cruzi