Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.

doi:10.1016/0165-1218(84)90047-8

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Article

Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.

Mutation research - 1 Jan 2000

Bruggeman I M, van der Hoeven J C

Abstract excerpt

Genotoxicity of emodin was studied in the Salmonella/microsome assay, the sister-chromatid exchange (SCE) assay and the hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) forward mutation assay with V79 Chinese hamster cells. In the Salmonella/microsome assay, emodin was found to be positive in TA97, TA100 and TA1537 in the presence of liver homogenate. In TA1537 a weak direct mutagenicity was also observed....

Topics

Animals
Anthraquinones
Biotransformation
Cell Line
Cricetinae
Cricetulus
Emodin
Hypoxanthine Phosphoribosyltransferase
Lung
Male
Microsomes, Liver
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Rats

Rats, Inbred Strains

Salmonella typhimurium

Sister Chromatid Exchange

Source

Open in PubMed

Identifiers

PMID: 6392875
DOI: 10.1016/0165-1218(84)90047-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6392875-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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