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Article

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Nature - 1 Jan 2000

Nusse R, van Ooyen A, Cox D, Fung Y K, Varmus H

Abstract excerpt

Most mammary carcinomas induced in C3H mice by the mouse mammary tumour virus (MMTV) bear a new proviral insertion within a highly conserved locus on chromosome 15 called int-1. A transcriptional unit within this locus is inactive in all tested normal tissues but expressed at low levels in mammar...

Topics

Animals
Biological Evolution
Cell Transformation, Viral
Chromosome Mapping
Female
Gene Expression Regulation
Mammary Neoplasms, Experimental
Mammary Tumor Virus, Mouse
Mice
Mutation
Oncogenes
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription, Genetic

Source

Identifiers

PMID: 6318122
DOI: 10.1038/307131a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6318122-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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