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Article

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Nature - 1 Jan 2000

Nusse R, van Ooyen A, Cox D, Fung Y K, Varmus H

Abstract excerpt

Most mammary carcinomas induced in C3H mice by the mouse mammary tumour virus (MMTV) bear a new proviral insertion within a highly conserved locus on chromosome 15 called int-1. A transcriptional unit within this locus is inactive in all tested normal tissues but expressed at low levels in mammary tumours with proviral insertions positioned on either the 5' and 3' sides of the gene. Transcription of the...

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PMID: 6318122
DOI: 10.1038/307131a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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