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Article

Retroviral transforming genes in normal cells?

Nature - 1 Jan 2000

Duesberg P H

Abstract excerpt

The hallmark of retroviral transforming genes (onc genes) are specific sequences which are unrelated to essential virion genes but are closely related to sequences in normal cells. Viral onc genes probably originated from rare transductions of these cellular sequences by retroviruses without onc genes. Consequently, it has been suggested that retroviral transforming genes are present in normal cells in a latent...

Topics

Animals
Cell Transformation, Neoplastic
Gene Amplification
Genes, Viral
Humans
Mutation
Neoplasms
Neoplasms, Experimental
Oncogenes
Retroviridae
Species Specificity
Transduction, Genetic

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Identifiers

PMID: 6346107
DOI: 10.1038/304219a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6346107-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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