Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host.

doi:10.1038/309462a0

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Article

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host.

Nature - 1 Jan 2000

Malpartida F, Hopwood D A

Abstract excerpt

The application of molecular cloning to antibiotic-producing microorganisms should lead to enhanced antibiotic productivity and to the biosynthesis of novel antibiotics by in vitro interspecific recombination. To allow such approaches, the genes for antibiotic synthesis must be isolated, analysed...

Topics

Anthraquinones
Anti-Bacterial Agents
Base Sequence
Cloning, Molecular
DNA Restriction Enzymes
DNA, Bacterial
Mutation
Streptomyces

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