Article
Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster.
Nature - 1 Jan 2000
Jackson F R, Wilson S D, Strichartz G R, Hall L M
Abstract excerpt
Voltage-sensitive sodium channels have a key role in the genesis of propagated action potentials. Mutations that affect these channels might be used like specific pharmacological agents in studies of channel structure and regulation. We have found that mutations which cause a reversible, temperature-induced paralysis in the fruit fly Drosophila melanogaster often affect the voltage-sensitive sodium channel. Using...
Topics
- Animals
- Cell Membrane
- Drosophila melanogaster
- Electric Conductivity
- Hydrogen-Ion Concentration
- Ion Channels
- Kinetics
- Mutation
- Saxitoxin
- Sodium