Article
Chemical basis of antigenic variation in foot-and-mouth disease virus.
Nature - 1 Jan 2000
Rowlands D J, Clarke B E, Carroll A R, Brown F, Nicholson B H, Bittle J L, Houghten R A, Lerner R A
Abstract excerpt
One of the difficulties in controlling foot and mouth disease by vaccination is the occurrence of the virus as seven distinct serotypes because immunity conferred by vaccination against one serotype leaves the animals susceptible to infection by the other six. Moreover, the antigenic variation, even within a serotype, can be so great that immunity against the homologous strain of virus need not necessarily ensure...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Viral
- Aphthovirus
- Base Sequence
- Cell Line
- Cricetinae
- DNA, Viral
- Genetic Variation
- Kidney
- Protein Conformation
- Virion