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Mutational specificities of 1'-acetoxysafrole, N-benzoyloxy-N-methyl-4-aminoazobenzene, and ethyl methanesulfonate in human cells.

Mutation research - 1 Jan 2000

Ingle C A, Drinkwater N R

Abstract excerpt

We have used an oriP-tk shuttle vector to determine the types of mutations induced in human cells by ethyl methanesulfonate (EMS), 1'-acetoxysafrole (AcOS), and N-benzoyloxy-N-methyl-4-aminoazobenzene (BzOMAB). Plasmid DNA was treated in vitro with mutagen and electroporated into human lymphoblastoid cells. After replication of the vector in human cells, plasmids were analyzed for mutations in the herpes simplex...

Topics

Azo Compounds
Chromosome Deletion
Dioxoles
Ethyl Methanesulfonate
Genetic Vectors
Humans
In Vitro Techniques
Mutagenicity Tests
Mutation
Plasmids
Safrole
Thymidine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

p-Aminoazobenzene

Source

Identifiers

PMID: 2927421
DOI: 10.1016/0165-1110(89)90019-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2927421-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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