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Eliminating manganese sensitivity and boosting citric acid production in Aspergillus niger through transporters manipulation.

Microbial cell factories - 6 Aug 2026

Márton Alexandra, Vandal Josee, Bíró Vivien, Fekete Erzsébet, Sándor Erzsébet, Kovács Béla, Tsang Adrian, Karaffa Levente

Abstract excerpt

BACKGROUND: Citric acid, a high-volume bioproduct, is manufactured by submerged fermentation using the filamentous fungus Aspergillus niger. Citric acid overflow requires Mn(II) ion concentrations not exceeding 5 µg L- 1. However, manganese easily leaches from media ingredients or stainless-steel bioreactors, necessitating costly, laborious removal. RESULTS: Aspergillus niger citrate fermentations were evaluated...

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Topics

Aspergillus niger
Citric Acid
Manganese
Fermentation
Bioreactors
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fungal Proteins

Membrane Transport Proteins

Biomass

Source

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Identifiers

PMID: 42778925
DOI: 10.1186/s12934-026-03082-y
PMCID: PMC13602490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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