Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Potential Role of the Gut-Vascular Axis in Ciprofloxacin-Associated Aggravation of Aortic Dissection.

Cardiovascular toxicology - 21 Sept 2026

Lv Hui, Wang Qi, Abudesimu Asiya, Yesitayi Gulinazi, Aizitiaili Aliya, Siti Dilixiati, Ma Xiang

Abstract excerpt

Ciprofloxacin (CIP) is associated with an increased risk of aortic dissection (AD); however, the underlying mechanism remains unclear. This study investigates the potential contribution of gut microbiota and intestinal barrier alterations to CIP-associated AD progression. The AD model was established using a combination of β-aminopropionitrile and angiotensin II. The composition of the gut microbiota was analyzed...

Read the complete abstract on PubMed

Topics

Animals
Ciprofloxacin
Humans
Disease Models, Animal
Male
Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lipopolysaccharides

Myocytes, Smooth Muscle

Gastrointestinal Microbiome

Cells, Cultured

Mice, Inbred C57BL

Intestinal Barrier Function

Apoptosis

Anti-Bacterial Agents

Bacteria

Dissection, Ascending Aorta

Angiotensin II

Aortic Dissection

Source

Identifiers

PMID: 42766226
DOI: 10.1007/s12012-026-10196-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Potential Role of the Gut-Vascular Axis in Ciprofloxacin-Associated Aggravation of Aortic Dissection.PMID 42766226Read ↗

Unraveling the Causal Nexus: Exploring the Relationship between Gut Microbiota and Aortic DissectionSemantic proximity Read ↗

Changes in the gut microbiome of patients with type a aortic dissectionSemantic proximity Read ↗

Mouse models of aortic dissection induced by β-aminopropionitrile combined with angiotensin II and the changes in their gut microbiotaSemantic proximity Read ↗

Causal effects of gut microbiome on aortic dissection: A mendelian randomization study.Semantic proximity Read ↗

Transcriptome Insights into Protective Mechanisms of Ferroptosis Inhibition in Aortic DissectionSemantic proximity Read ↗

Supplementary Elevated triglycerides predispose patients to aortic dissection by increasing inflammasome-induced pyroptosisSemantic proximity Read ↗

Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰Semantic proximity Read ↗

Tirzepatide mitigates thoracic aortic aneurysm and dissection by alleviating the loss of the contractile phenotype in vascular smooth muscle cells and reducing vascular inflammation.Semantic proximity Read ↗

Effects of gut microbiota and gut-derived lipopolysaccharide on patients with coronary heart diseaseSemantic proximity Read ↗

Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice-Brief Report.Semantic proximity Read ↗

The gut microbiota in experimental abdominal aortic aneurysmSemantic proximity Read ↗

Identification of Serum Biomarkers and Therapeutic Targets for Aortic Diseases in Obesity through Multi-Omics AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.