Mouse models of aortic dissection induced by β-aminopropionitrile combined with angiotensin II and the changes in their gut microbiota

Abstract excerpt

BACKGROUND: Aortic dissection (AD) is a lethal vascular disease with no effective pharmacological treatments currently available. The construction of mouse models is crucial for researching the pathogenesis of AD. The gut microbiota play a role in the progression of AD, but studies on their changes in AD mouse models are lacking. This study compares various strategies for constructing mouse models of acute AD and...

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